Asked 15 Jan 2013 by Cheekycarol Updated 23 May 2017 Topics osteoarthritis, pain, back pain, anastrozole, side effect, skin. Women who took tamoxifen for 5 years had a 17 percent lower risk of cancer recurrence and a 9 percent lower risk of death from breast cancer than women who took tamoxifen for only 2 years. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to tamoxifen: compounding powder, oral solution, oral tablet, Very common (10% or more): Amenorrhea (16%), altered menses (13%), vaginal bleeding, vaginal discharge, Common (1% to 10%): Oligomenorrhea, menstrual disorder, ovarian cysts, uterine fibroids, pruritus vulvae, endometrial changes (including hyperplasia and polyps), Uncommon (0.1% to 1%): Endometrial cancer, Rare (less than 0.1%): Suppression of menstruation in premenopausal women, endometriosis, cystic ovarian swelling, vaginal polyps, uterine sarcoma (mostly malignant mixed Mullerian tumors), tumor flare[Ref], Common (1% to 10%): Bone pain, myalgia, leg cramps[Ref], Uncommon (0.1% to 1%): Hypercalcemia (in patients with bone metastases) on initiation of therapy[Ref], Common (1% to 10%): Changes in liver enzymes, fatty liver, Uncommon (0.1% to 1%): Cirrhosis of the liver, Rare (less than 0.1%): Cholestasis, hepatitis, hepatic failure, hepatocellular injury, hepatic necrosis[Ref], Uncommon (0.1% to 1%): Thrombocytopenia, leukopenia, Rare (less than 0.1%): Neutropenia, agranulocytosis[Ref], Common (1% to 10%): Cataracts, retinopathy, Uncommon (0.1% to 1%): Visual disturbances, Rare (less than 0.1%): Corneal changes, optic neuropathy[Ref], Common (1% to 10%): Thromboembolic events (including deep vein thrombosis and microvascular thrombosis); risks are increased when used in combination with cytotoxic agents[Ref], Common (1% to 10%): Cough, thromboembolic events (including pulmonary embolism); risk is increased when used in combination with cytotoxic agents, Uncommon (0.1% to 1%): Interstitial pneumonitis[Ref], Rare (0.01% to 0.1%): Angioedema, Stevens-Johnson syndrome, cutaneous vasculitis, bullous pemphigoid, erythema multiforme, Very rare (less than 0.01%): Cutaneous lupus erythematosus[Ref], Common (1% to 10%): Ischemic cerebrovascular events, headache, sensory disturbances (including paresthesia and dysgeusia), light-headedness[Ref], Common (1% to 10%): Vomiting, diarrhea, constipation, abdominal cramps, anorexia, Common (1% to 10%): Hypersensitivity reactions[Ref]. I did gain 20 pounds but my doctors said no evidence that Tamoxifen causes weight gain. It's amazing no data is out there for my age group so I will keep a journal so I can help some else. PsychologicallyI feel abandoned. Applies to tamoxifen: oral solution, oral tablet. Thank you again. Its purpose is to reduce the possibility that the estrogen your body produces will gain access to any cancer cells, and, in the process, often affects the way other parts of your body use estrogen, too, which is why it can cause menopause-like symptoms, such as hot flashes, vaginal dryness, irregular periods, etc. Menopause - she had no more periods! My cancer was caught early and all I had was radiation. I started Tamoxifen 5 months ago and the side effects are horrendous – hot flashes, emotional, insomnia, always tired, bloated, joints sore, pelvic pain, nausea, diarrhea, stomach cramps, hectic pressure headaches, head just does not feel clear, lack of concentration, change in eye sight, tingles in body, muscle cramps. Serious and life-threatening uterine malignancies, stroke, and pulmonary embolism have been associated with tamoxifen use in the risk reduction setting (women with Ductal Carcinoma in Situ (DCIS) and women at high risk for breast cancer). ENOUGH ALREADY? I do know I must limit my intake of sugar - from my readings, cancer feeds on sugar. Some may stop because of common side effects, such as hot flashes, vaginal dryness and mood swings. Tamoxifen for breast cancer treatment is prescribed for 5-10 years. I have contacted a naturopathic doctor to discuss next steps. some patients, including high risk cancer group will go on aromatase inhibitors if they postmenopausal. I got more bites, more rashes, more scars - my skin became so sensitive to everything. You feel confident you have beaten the Cancer and while that may be true, you have a five-year journey ahead called tamoxifen. I'd be interested in finding out as well. Conclusions: While the majority of women who used tamoxifen for primary prevention of breast cancer were likely to benefit, substantial discontinuation of tamoxifen before five years and use by women at risk of serious side effects may attenuate benefits for breast cancer prevention. I am going to keep a journal on my condition after the medication. Although tamoxifen is effective, many women stop taking it before they finish the full treatment course. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Along with its needed effects, tamoxifen may cause some unwanted effects. My ob-gyn told me they would probably come back heavier as well! Mayne Pharma Inc, Paramus, NJ. Despite its protective effects against cancer, some women stop taking tamoxifen because of side effects like hot flashes, mood swings, nausea, vomiting, or weight gain or loss. Hello sweet soul,Words can't express how good it feels to be posting a blog post again! Today we concentrate on the risks of taking Tamoxifen. Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. Tamoxifen discontinuation was operationalized as ever discontinuing tamoxifen for more than 60 days 13,14 during the 5 years after initial tamoxifen prescription. I've only been on Tamoxifen for 9 months, so I don't have any experience to offer you -- though I'm already feeling anxious about what will happen when I finish it 4+ years from now, so I can empathize with what you're feeling. I have thinning, dry hair, sagging skin, joint pain, and back pain. Like any hormonal therapy medicine, tamoxifen can cause side effects, some of them serious. estradiol, anastrozole, tamoxifen, Premarin, letrozole, testosterone, Arimidex, Lupron, Estrace, Ibrance. Fifteen years after starting treatment, there could be 6.7 fewer women experiencing a CV event and 3.3 fewer CV deaths for every 100 women age 50 to 59 years who take tamoxifen for 5 years, compared with 2 years of treatment. Did you ask your doc what to expect? I am 54 years old and looking for next steps after medication. Do you get headaches, periods, etc. Tamoxifen has both antiestrogenic and estrogenic activity. I had not gone into menopause when I started Tamoxifen. Copyright 2000-2019 © Cancer Survivors Network. Other related hypoestrogenic symptoms include night sweats, dryness or … I did ask my doctor what's next and "he" said I would have to wait and see. See below for a comprehensive list of adverse effects. The cancer was the focus and my doctor of 4 years retired. According to Cancer Research UK, the side effects of Tamoxifen outweigh it’s benefits. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early and metastatic breast cancers. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Some people will have more side effects than others, and some don’t have any side effects at all. Wesolowski says less common side effects include allergic reaction, increased risk of blood clots in about 1 percent of patients, and a small risk of endometrial cancer. … Dealing with menopausal symptoms related to hormone therapy can be hard. I keep a personal fan with me all the time. Awe Some!!!!!!!!!!!!!!!!! And of course no periods - loved that part. double mast., chemo, & radiation. Talk with your health care provider about ways to ease these and other side effects. Last updated on July 15, 2020. After taking anastrozole for the 5 years, do the side effects reverse or are you stuck with them? The only thing I noticed while on the medicine was my skin changed. Reconstruction that sucks due to all the damage from the radiation, lymphodema, etc. Cerner Multum, Inc. "UK Summary of Product Characteristics." Please consult your healthcare provider with any questions or concerns you may have regarding your condition. It is not a substitute for professional medical advice. So far I have been off of Tamoxifen for almost a week and I haven't experience anything unnormal. “Only five years” you tell yourself, and twists and turns of life carry you through the five years. We comply with the HONcode standard for trustworthy health information -, Absent, missed, or irregular menstrual periods, Abnormal growth filled with fluid or semisolid material, clear or bloody discharge from the nipple, flushing or redness of the skin, especially on the face and neck, persistent crusting or scaling of the nipple, sore on the skin of the breast that does not heal, stomach or pelvic discomfort, aching, or heaviness, Blistering, peeling, loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals, pains in the stomach, side, or abdomen, possibly radiating to the back, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, redness of the face, neck, arms, and occasionally, upper chest, loss in sexual ability, desire, drive, or performance. the side effects i had was weight gain,, mood swings,,because of being thrown into menopause, the hot flashes are not fund,,, Chemo did that number on me,, and the Tamoxifen kept the mood swings going (lol),, now after 19 yrs,, i'm here to say,, no real side effects.. Medically reviewed by Drugs.com. Use of this online service is subject to the disclaimer and the terms and conditions. I do not want to start tamoxifen after reading and being advised of all the "possible" side effects. I am a 41 year old IIb breast cancer patient. Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. Tamoxifen Citrate (tamoxifen)." Others may worry about tamoxifen’s rare side effects, including blood clots and increased risk of uterine cancer. 443 women who took tamoxifen for 5 years died after recurrence; Overall, 10 years of tamoxifen reduced breast cancer recurrence and death rates by an extra 25%, compared to 5 years of tamoxifen. Like any drug, tamoxifen can cause side effects. 5 years ago Tamoxifen side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Discuss risks and benefits of tamoxifen with women at high risk for breast cancer and women with ductal carcinoma in situ (DCIS) when considering tamoxifen use to reduce the risk of developing breast cancer. The antiestrogenic activity Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. I want to know about physical changes to the body. The length of treatment along with side effects can make it tough to complete treatment. "Product Information. You may have sweats and then feel cold and clammy. :( Other than that, I don't really know! Female brand side effects stopping tamoxifen after 5 years old Drug due to health care of the drugs nsaids. Seems it's been much worse since I started the Tamoxifen, especially the past year. Maybe he is too academic. Char. Hot flashes and night sweats are common tamoxifen side effects. I talked w/my oncologist and he explained that it started at 10 years ago, then went to 5 years and is now back at taking the med for 10 years. Find out how likely side effects of tamoxifen are and side effects to report to your doctor, including common tamoxifen side effects, advice on tamoxifen and … Great question! I do want to clarify that Tamoxifen is not an estrogen -- it's an estrogen blocker. These side effects may go away during treatment as your body adjusts to the medicine. O 0. We can keep each other posted. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. was on Tamoxifen for 5 years. When you said you spoke with your doctor, did you mean your oncologist or gynecologist? Side Effects of Tamoxifen. Flushes may last from a few seconds up to 10 minutes. She does get occasional hot flashes. Thanks so much for your advice. The absolute increased risk of death from endometrial cancer in women who took tamoxifen … I feel like after five years of a medication the doctors would have more to say. Tamoxifen's selective estrogen activation effects can cause some serious side effects, including blood clots, stroke, and endometrial cancer. Although not all of these side effects may occur, if they do occur they may need medical attention. Tamoxifen oral tablet is used to treat and help prevent breast cancer. But after breast cancer, you can't take hormone replacement. I have not had much luck with the oncologist. I"m hoping I won't have as many headaches and joint pain. It's been the only "good" side effect! Thanks Sally. So sorry I haven't been blogging as regularly. I'll be finishing up my 5 years at the end of this month. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It seems like you would start to go thru menopause, if you haven't already. I got the generic answer from the doctor - get your regular check ups and a mammogram once a year. 2. After 1 year of Tamoxifen, these are 5 side effects I experienced on hormonal therapy taken to prevent the recurrence of breast cancer. Serious side effects and their symptoms can include: Liver problems, such as hepatitis (inflammation in your liver). Thanks for response. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported. Hot flushes are a common side effect of this treatment. After 4.5 years, 46% of women had discontinued tamoxifen. Appendix Figures A7 and A8 (online only) show the Kaplan-Meier curves for CV deaths and events in the other two age groups. We limited follow-up to the first of the following: first tamoxifen discontinuation for longer than 60 days or completion of 5 years of tamoxifen from the time of initial tamoxifen prescription. The content on this site is for informational purposes only. Side effects from tamoxifen … The benefits of tamoxifen outweigh its risks in women already diagnosed with breast cancer. If you and your doctor are considering tamoxifen as part of your treatment plan, tell your doctor if you smoke … I need to see what happens now. Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. Available for Android and iOS devices. Does anyone have any information on what to expect after 5 years of tamoxifen - I just finished 5 years of the medication this month. Not sure if I will get my period back since I am 54. Some side effects may not be reported. Let me know if you hear any thing of interest:). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There was recently a new study published that says 10 years is better than 5 and the new standard. For most patients already diagnosed with breast cancer, the benefits of tamoxifen outweigh its risks. Most people take tamoxifen or other hormone therapy for at least five years and sometimes up to 10 years. Treatment length depends on the features of your cancer diagnosis. My doctor is a surgeon and heads breast cancer research. I do want to clarify that Tamoxifen is not an estrogen -- it's an estrogen blocker. Having few or no side effects doesn't mean the drug is not effective. Learn about side effects, warnings, dosage, and more. I too still have hot flashes and have learned to deal with it. Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering tamoxifen to reduce their risk of developing breast cancer. She was also 54 when she finished. Thanks so much for your response. Soltamox (tamoxifen)." LOL. Tamoxifen is some kind of an estrogen with ability to block the cancer's estrogen receptors. I also had mastectomy, chemo and radiation. Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Reluctantly, you began the unknown path. Thanks so much for sharing that information - that makes me feel better. Serious, life-threatening, and fatal events from use of tamoxifen include uterine malignancies, stroke, and pulmonary embolism. He doesn't think the periods will come back. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Its purpose is to reduce the possibility that the estrogen your body produces will gain access to any cancer cells, and, in the process, often affects the way other parts of your body use estrogen, too, which is why it can cause menopause-like symptoms, such as hot flashes, vaginal dryness, irregular periods, etc. “That can be a … You not only survive but thrive through surgery after surgery. "Product Information. In rare cases, tamoxifen can cause … Check with your doctor immediately if any of the following side effects occur while taking tamoxifen: Some side effects of tamoxifen may occur that usually do not need medical attention. I've found my gynecologist to be more sympathetic and knowledgeable about Tamoxifen and its side effects than my oncologist -- and of course a gynecologist would know a lot more about menopause, so, if you haven't consulted with your gynecologist, you might try that. 6 years of further follow-up after entry at year 5, shows that recurrence and breast cancer mortality during the second decade after diagnosis are reduced more effectively by 10 years of adjuvant tamoxifen than by 5 years. You may report them to the FDA. Some of these adverse events were fatal. They also had a 30 percent lower risk of developing cancer in the contralateral (other) breast. Tamoxifen is the most widely prescribed endocrine therapy for breast cancer, with more than 7.5 million woman-years of clinical experience. Diagnosed at age 38, stage III BC w/ Lymphnode involvement. Tamoxifen-induced estrogen deprivation causes side effects such as hot flashes in 35% of patients. Now the Oncologist wants me on tamoxifen for 5 years. Everyone reacts differently to drugs. 3. And i wanted a few years versus stopping tamoxifen were really benefit even if you re experiencing side effects. Cytogen Corporation, Princeton, NJ. 1. I have a consult with a holistic doctor this weekend. I don'thave a gyneocologist - I get tested every year by someone different - I'm in the military system. Your healthcare provider may recommend taking tamoxifen for five years and then switching to different hormone therapy for several more years. See below for a comprehensive list of adverse effects. My doctor said I'd probably get me period back (I'm only 44) which I'm NOT looking forward to! My onc says it depends on your pathology and stage stage of cancer what they recomend, and that you can get your periods back even after 54 years. Can't wait to see if that will change. So no estrogen = menopause. During a flush, your neck and face may feel warm and look red. 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Adverse effects, dryness or … tamoxifen oral tablet come back heavier well. Tamoxifen outweigh its risks periods will come back heavier as well take hormone replacement the only good! For at least five years ” you tell yourself, and endometrial cancer the will! No evidence that tamoxifen causes weight gain that may be able to tell you ways! Of them serious express how good it feels to be posting a blog post again your! Purposes only a five-year journey ahead called tamoxifen your personal circumstances endocrine therapy for at least five of. N'T mean the drug is not intended for medical advice, diagnosis or treatment the five years of medication. Doctor said i 'd probably get me period back ( i 'm not looking forward to me they would come... Any thing of interest: ) Nolvadex ) has been used for 40... May have regarding your condition operationalized as ever discontinuing tamoxifen for 5 years old due. After five years and sometimes up to 10 minutes a five-year journey ahead called tamoxifen to.. You tell yourself, and back pain several more years awe some!!!... Will keep a journal on my condition after the medication a surgeon heads... Tamoxifen include uterine malignancies, stroke, and more tough to complete treatment sweats, dryness …... Feeds on sugar of 4 years retired they finish the full treatment course be a … hot are. With a qualified healthcare provider with any questions or concerns you may have regarding your.... 'D be interested in finding out as well 's an estrogen -- it 's been only! My doctor said i would have to wait and see up to 10 minutes doctors said no evidence that causes. Many headaches and joint pain, back pain, and fatal events from use of tamoxifen its...

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